Growth hormone (GH) is a protein hormone produced by anterior pituitary growth hormone cells. Growth hormone is necessary for normal growth, besides increasing height, it plays an important role in the function of heart and kidney, the growth and development of skin, viscera, skeleton, muscle and gonad, and has great influence on the metabolism of sugar, fat and protein.
Although growth hormone deficiency, unlike diabetes caused by insulin deficiency, does not use insulin will immediately appear life-threatening, but also can cause short, osteoporosis, muscle dysplasia, susceptibility to cardiovascular disease, sexual dysplasia, aging and a series of abnormal manifestations.
Recombinant human growth hormone is the only drug approved by the US FDA to promote children's growth.
The U.S. Food and Drug Administration (FDA), the world's most stringent drug review body, approved growth hormone indications
In recent years, rhGH has also been found to be effective in the treatment of anti-aging and weight loss. A study in the Netherlands suggests that rhGH can promote intellectual development to some extent.
Growth hormone is a protein whose molecular weight is about 22KD. If taken orally, it will be decomposed.
At present, rhGH is used in the same way as insulin, lyophilized powder is injected by disposable syringe after the injection water is dissolved.
Water can be injected by hidden pin electronic pen. Because the child could not see the needle to reduce the fear, 5mm electronic pen needle was very thin, 77% of the children would not feel pain. Short acting growth hormone is injected once every night about 1 hours before bedtime.
Long acting weekly growth hormone can be fixed once a day.
And the parents asked, can the tall medicine be long enough to eat?
The function of health food approved by the Ministry of health has not increased.
If the ingredients contained in health products are just missing from children, they may have a long and high effect.
However, due to the different reasons for each child's growth retardation, whether lack and lack of which nutrients, it is necessary to go to a regular hospital for laboratory testing, specific lack of a supplement is the best;
The clinical efficacy of growth hormone is the most significant for those with growth hormone deficiency. In the absence of other diseases, those with younger bone age before puberty can generally grow 8-12 CM per year.
However, with the increase of bone age, the growth rate and the increase of lifetime height will gradually decrease.
Therefore, it is suggested that early detection and early treatment should be made. The best expectation is about 4-12 years old.
Analysis of the causes of poor efficacy of growth hormone therapy?
1. Is the dose of growth hormone adequate?
2. Growth hormone powder produces antibodies.
4. Use glucocorticoids.
5. Epiphyseal plate closure.
6, the measurement is inaccurate;
7, there are systemic chronic diseases.
8, growth hormone treatment is invalid.
9. Do children insist on using growth hormone continuously?
10, do you usually do not match your life (such as psychological factors, stress, diet and exercise)?
To achieve the best therapeutic effect as far as possible, we need to make efforts from many aspects.
First of all, we must exclude some diseases that are not suitable for auxin treatment. After all, safety is the most important thing.
Secondly, the etiology of the disease should be examined and differentiated, and bone age should be evaluated in detail, auxin stimulation test and other related examinations should be done regularly to determine the dosage of auxin.
Third, we need to examine the liver and kidney function, thyroid hormone and other factors that may affect the efficacy of auxin, if necessary, timely correction;
The fourth is regular review and timely adjustment of ghrelin dose.
The fifth is regular safety monitoring.
The sixth is the choice and cooperation between parents and patients.